FirstName_37889 LastName_37889

13.05.1964

FirstName_37889 LastName_37889

13.05.1964

Career

Institution and position
2004–...    Protobios LLC, lead researcher (1,00)
2005–31.12.2016    Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Molecular Biology, Senior Researcher (0,25)
2003–31.12.2016    Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Molecular Biology, Associate Professor (0,25)
01.01.2003–31.12.2005    01.02.2003 - 02.02.2005 research scientist National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
01.01.1998–31.12.1998    07/1998-10/1998 postdoctoral student, BMC, Uppsala University, Sweden
01.01.1998–31.12.1998    10/1998- 05/ 2001 research fellow, Cedars-Sinai Medical Center, Los Angeles, USA
01.01.1995–31.12.1998    03/1995- 06/1998 PhD student, Karolinska Institute, Stockholm, Sweden'

Qualifications

 
 
Additional information
PhD, medical sciences
Karolinska Institute, Stockholm, Sweden, 1998

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2016
1.1.
2016
1.1.
2016
1.1.
2015
1.1.
2015
1.1.
2014
1.1.
2014
1.1.
2013
1.1.
2010
1.1.
2009
1.1.
2009
1.1.
2009
5.1.
2008
1.1.
2007
1.1.
2007
5.1.
2006
1.1.
2002
1.1.
2002
1.1.
2001
1.1.
2000
1.1.
1999
1.1.
1999
1.1.
1998
1.1.
1995
1.1.
1995
1.1.
1993
1.1.
1993
1.1.
1993
  • Leitud 18 kirjet
ProgrammNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusRahastamine kokku
MUUEU612308Academic Industry R&D Opportunities for Picornaviruses01.10.201430.09.2019FirstName_722215 LastName_722215Protobios OÜ232 321,00 EUR
MUU602LAju arengu molekulaarsed uuringud05.01.200631.12.2010FirstName_717408 LastName_717408Tallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut2 678,41 EUR
1.2.2.1.EU734791Development of molecular tools for early detection of schizophrenia01.01.201731.12.2020FirstName_1142882 LastName_1142882Protobios OÜ180 000,00 EUR
ETFETF5555Drosophila neuralized geeni homoloogid imetajates01.01.200331.12.2006FirstName_727953 LastName_727953Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond39 829,73 EUR
IUTIUT19-18Geeniekspressiooni ja signaaliülekande regulatsioon närvisüsteemis ja selle patoloogiates01.01.201431.12.2019FirstName_1025289 LastName_1025289Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut; Tallinna Tehnikaülikool, Loodusteaduskond, Keemia- ja biotehnoloogia instituut768 000,00 EUR
SFSF0222602s03Geeniekspressiooni regulatsioon närvisüsteemis.01.01.200331.12.2007FirstName_734179 LastName_734179Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond182 979,05 EUR
SFSF0140143s08Geeniregulatsioon ja signaaliülekanne närvisüsteemis01.01.200831.12.2013FirstName_728896 LastName_728896Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond837 015,63 EUR
MUUTAR16018Genoomika ja Siirdemeditsiini Tippkeskus01.01.201601.03.2023FirstName_721737 LastName_721737Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaarbioloogia õppetool344 181,21 EUR
MUU1-2016Informaatilise töövoo arendus inimese immunoomi kirjeldamiseks01.01.201001.02.2017FirstName_722195 LastName_722195Protobios OÜ100 000,00 EUR
1.2.2.1.COST BM1406 (BMBS COST Action BM1406)Ion Channels and Immune Response toward a global understanding of immune cell physiology and for new therapeutic approaches (IONCHAN-IMMUNRESPON)14.11.201430.03.2019FirstName_730626 LastName_730626Protobios OÜ30 000,00 EUR
MUUEU602694Local immunomodulation around implants by innovative auxiliary hydrogel-based systems encapsulating autologous and phenotype controlled macrophages 01.10.201330.09.2017FirstName_722212 LastName_722212Protobios OÜ619 942,00 EUR
MUUMODEST-037291 (037291)Modular devices for ultrahigh-throughput and small-volume transfection04.04.200704.04.2010FirstName_712879 LastName_712879Protobios OÜ183 446,56 EUR
MUUEU27549Peptiidsete ravimikandidaatide rakendusuuring01.01.200831.12.2009FirstName_714792 LastName_714792Protobios OÜ317 909,32 EUR
MUUEU21276Rakendusuuring rakuteraapia tehnoloogia ja rakukiipide väljatöötamiseks01.08.200531.12.2007FirstName_720569 LastName_720569Protobios OÜ530 339,82 EUR
MJDMJD266Rasvkoest pärinevate mesenhümaalsete tüvirakkude kemotaktilise migratsiooni ning diferentseerumisvõime uurimine01.11.201131.12.2015FirstName_729519 LastName_729519Protobios OÜ94 080,00 EUR
ETFETF7257Transkriptsiooni häired Huntingtoni tõves01.01.200731.12.2010FirstName_727073 LastName_727073Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond66 140,90 EUR
MUU589LVähiuuringute Tehnoloogia Arenduskeskuse ning TTÜ GTI vaheline leping01.05.200528.02.2008FirstName_717379 LastName_717379Tallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Geenitehnoloogia õppetool57 520,48 EUR
MUUEU675746‘Immunoprofile-directed stratification of patients with the autoimmune disorder thrombotic thrombocytopenic purpura’ 01.04.201528.02.2019FirstName_722213 LastName_722213Protobios OÜ90 000,00 EUR
  • Leitud 31 kirjet
PublikatsioonKlassifikaatorFail
Inahashi, Y.; Shiraishi, T.; Palm, K.; Takahashi, Y.;,Ōmura, S.; Kuzuyama, T.; and Nakashima, T. (2016). Biosynthesis of trehangelin in Polymorphospora rubra K07-0510: identification of metabolic pathway to angelyl-CoA. Chembiochem : a European journal of chemical biology, x−x [_isbeingpublished].1.1.
Sadam, H.; Liivas, U.; Kazantseva, A.; Pruunsild, P.; Kazantseva, J.; Timmusk, T.; Neuman, T.; Palm, K. (2016). GLI2 cell-specific activity is controlled at the level of transcription and RNA processing: Consequences to cancer metastasis. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1862 (1), 46−55, 10.1016/j.bbadis.2015.10.008.1.1.
Kazantseva, J.; Ivanov, R.; Gasik, M.; Neuman, T.; Hussainova, I. (2016). Graphene-augmented nanofiber scaffolds demonstrate new features in cells behaviour. Scientific Reports, 30150.1.1.
Kazantseva, Jekaterina; Sadam, Helle; Neuman, Toomas; Palm, Kaia (2016). Targeted alternative splicing of TAF4: a new strategy for cell reprogramming. Scientific reports, 6, 30852−30852, 10.1038/srep30852.1.1.
Lend, AK; Kazantseva, A; Kivil, A; Valvere, V; Palm, K. (2015). Diagnostic significance of alternative splice variants of REST and DOPEY1 in the peripheral blood of patients with breast cancer. Tumor Biology, 36 (4), 2473−2480.1.1.
Kazantseva, J.; Tints, K.; Neuman, T.; Palm, K. (2015). TAF4 controls differentiation of human neural progenitor cells through hTAF4-TAFH activity. Journal of Molecular Neuroscience , 55 (1), 160−166, 10.1007/s12031-014-0295-6.1.1.
Kazantseva, Jekaterina; Palm, Kaia. (2014). Diversity in TAF proteomics: consequences for cellular differentiation and migration. International Journal of Molecular Sciences, 15 (9), 16680−16697.1.1.
Tints, K; Prink, M; Neuman, T; Palm, K. (2014). LXXLL peptide converts transportan 10 to a potent inducer of apoptosis in breast cancer cells. International Journal of Molecular Sciences, 15 (4), 5680−5698.1.1.
Kazantseva, Jekaterina. (2014). Alternative Splicing of TAF4: A Dynamic Switch between Distinct Cell Functions. (Doktoritöö, Tallinna Tehnikaülikool). TUT Press.2.3.
Kazantseva, Jekaterina; Kivil, Anri;Tints, Kairit; Kazantseva, Anna; Neuman, Toomas; Palm, Kaia (2013). Alternative splicing targeting the hTAF4-TAFH domain of TAF4 represses proliferation and accelerates chondrogenic differentiation of human mesenchymal stem cells. PLoS ONE, 8 (10), e74799, 10.1371/journal.pone.0074799.1.1.
Koppel, I.; Aid-Pavlidis, T.; Jaanson, K.; Sepp, M.; Palm, K.; Timmusk, T. (2010). BAC transgenic mice reveal distal cis-regulatory elements governing BDNF gene expression. Genesis, 48, 214−219.1.1.
Kazantseva, A.; Sepp, M.; Kazantseva, J.; Sadam, H.; Pruunsild, P.; Timmusk, T.; Neuman, T.; Palm, K. (2009). N-terminally truncated BAF57 isoforms contribute to the diversity of SWI/SNF complexes in neurons. Journal of Neurochemistry, 109 (3), 807−818, 10.1111/j.1471-4159.2009.06005.x.1.1.
Rullinkov, G.; Tamme, R.; Sarapuu, A.; Lauren, J.; Sepp, M.; Palm, K.; Timmusk, T. (2009). Neuralized-2: expression in human and rodents and interaction with Delta-like ligands. Biochemical and Biophysical Research Communications, 389, 420−425.1.1.
Koppel, I.; Aid-Pavlidis, T.; Jaanson, K.; Sepp, M.; Pruunsild, P.; Palm, K.; Timmusk, T. (2009). Tissue-specific and neural activity-regulated expression of human BDNF gene in BAC transgenic mice. BMC Neuroscience, 10, 68.1.1.
Sadam, Helle; Verev, Helen; Kazantseva, Jekaterina; Neuman, Toomas; Palm, Kaia (2009). Characterization of physical and functional interaction of BRN2 with the subunits of the RNA polymerase II transcriptional Mediator. <i>bHLH transcription factors : EMBO bHLH transcription factors Workshop, London, UK, 7-8 may 2009.</i> Ed. European Molecular Biology Organization. European Molecular Biology Organization, P26.5.2.
Vinkel, K.; Kivil, A.; Neuman, T.; Palm, K . (2008). Using gene expression profiling to differentiate breast and colon tumors. Cellular Onkology, 30 (2), 163.5.1.
Pruunsild Priit, Kazantseva Anna, Aid Tamara, Palm Kaia, Timmusk Tõnis (2007). Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics, 90, 397−406.1.1.
Aid, T; Kazantseva, A.; Piirsoo, M.; Palm, K.; Timmusk, T. (2007). Mouse and rat BDNF gene structure and expression revisited. Journal of Neuroscience Research, 85, 525−535.1.1.
Maloverjan, A.; Kazantseva, A.; Liik, A.; Palm, K.; Neuman, T . (2006). Manipulating transcriptional control of ECM homeostasis: A novel strategy to rejuvenate skin. Journal of Investigative Dermatology, 126, 39.5.1.
Timmusk, T.; Palm, K.; Belluardo, N.; Mudo, G.; Neuman, T. (2002). Dendritic localization of mammalian neuralized mRNA encoding a protein with transcription repression activities. Molecular and Cellular Neuroscience, 20 (4), 649−668, 10.1006/mcne.2002.1148.1.1.
Mizuguchi, T.; Palm, K.; Hui, T.; Aoki, T.; Mochizuki, Y.; Mitaka, T.; Demetriou, AA.; Rozga, J. (2002). Effects of bone marrow stromal cells on the structural and functional polarity of primary rat hepatocytes. In Vitro Cellular and Developmental Biology - Animal, 38 (2), 62−65.1.1.
Mizuguchi, T; Hui, T; Palm, K; Sugiyama, N; Mitaka, T; Demetriou, AA; Rozga, J. (2001). Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells. Journal of Cellular Physiology, 189 (1), 106−119.1.1.
Palm, K.; Salin-Nordström, T.; Levesque, M. F.; Neuman, T. (2000). Fetal and adult human CNS stem cells have similar molecular characteristics and developmental potential. Molecular Brain Research, 78, 192−195.1.1.
Timmusk, T.; Palm, K.; Lendahl, U.; Metsis, M (1999). Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. Journal of Biological Chemistry, 274 (2), 1078−1084.1.1.
Palm, Kaia; Metsis, Madis; Timmusk, Tõnis (1999). Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Molecular Brain Research, 72 (1), 30−39.1.1.
  • Leitud 11 kirjet
PealkiriJuhendatavKraadJuhendajaKaitsmise staatusKaitsmise aastaAsutus
Alternative splicing in health and diseaseLastName_694180, FirstName_694180doktorikraadFirstName_694180 LastName_694180Kaitstud2016Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
Alternative splicing of TAF4: a dynamic switch between distinct cell functionsLastName_694667, FirstName_694667doktorikraadFirstName_694667 LastName_694667Kaitstud2014Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
Cancer-specific transcription preinitiation complexes: studies of expression and function - doktorikraadFirstName_630010 LastName_630010; FirstName_630010 LastName_630010JuhendamiselTallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
Elektrilised meetodid patogeenide tuvastamiseksLastName_644252, FirstName_644252doktorikraadFirstName_644252 LastName_644252; FirstName_644252 LastName_644252; FirstName_644252 LastName_644252JuhendamiselTallinna Tehnikaülikool, Infotehnoloogia teaduskond, Thomas Johann Seebecki elektroonikainstituut, Siduselektroonika teaduslabor
Mouse and Rat BDNF Gene Structure Revisited: BAC Transgenic Constructs for Studying Regulation of BDNF Gene Expression in vivo - magistrikraad (teaduskraad)FirstName_629713 LastName_629713; FirstName_629713 LastName_629713Kaitstud2005Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
NEURALIZED FAMILY: STUDIES OF GENE EXPRESSION AND PROTEIN LOCALIZATION. TRANSCRIPTIONAL INTERFERENCE IN THE NEU-4 GENE LOCUS - magistrikraad (teaduskraad)FirstName_629710 LastName_629710; FirstName_629710 LastName_629710Kaitstud2006Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
Proneuraalse valgu BRN2 aktiivsuse uurimine melanoomides ja naha fibroblastidesLastName_695711, FirstName_695711magistrikraadFirstName_695711 LastName_695711; FirstName_695711 LastName_695711Kaitstud2013Tallinna Tehnikaülikool, Loodusteaduskond
RNAi and peptide based drug development - magistrikraadFirstName_652249 LastName_652249Kaitstud2009Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaarbioloogia õppetool
Structure and Regulation of BDNF Gene - doktorikraadFirstName_694668 LastName_694668; FirstName_694668 LastName_694668; FirstName_694668 LastName_694668Kaitstud2010Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
The use of alternatively spliced mRNAs in breast and colon cancer diagnostics - magistrikraad (teaduskraad)FirstName_652248 LastName_652248Kaitstud2008Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
Transkriptsiooni rakuspetsiifilised kompleksid - doktorikraadFirstName_652250 LastName_652250JuhendamiselTallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
  • Leitud 8 kirjet
TüüpPrioriteedi numberPrioriteedi kuupäevPrioriteedi klassifikaatorPealkiriAutoridFailAsutused
Patentne leiutisUS12/707,60717.02.2010Rahvusvaheline (IPC)Ex vivo progenitor and stem cell expansion and differentiation for use in the treatment of disease of the nervous systemFirstName_703910 LastName_703910; FirstName_703910 LastName_703910Protobios OÜ
Patentne leiutisUS2001080838714.03.2001Rahvusvaheline (IPC)Mammalian neuralized family transcriptional regulators and usesFirstName_703721 LastName_703721; FirstName_703721 LastName_703721CEMINES INC
Patentne leiutisUS20040584784P30.06.2004Rahvusvaheline (IPC)Methods and compositions for the diagnosis, prognosis and treatment of cancerFirstName_703836 LastName_703836; FirstName_703836 LastName_703836; Daiwei ShenCEMINES INC
Patentne leiutisUS20020436693P; US2003074654726.12.2002Rahvusvaheline (IPC)Methods and compositions for the diagnosis, prognosis, and treatment of cancerFirstName_703722 LastName_703722; FirstName_703722 LastName_703722CEMINES LLC
Patentne leiutisUS 14/079,62613.11.2013Rahvusvaheline (IPC)Peptiidide profileerimine ja humoraalse immuunsuse monitooringFirstName_702904 LastName_702904; FirstName_702904 LastName_702904; FirstName_702904 LastName_702904; FirstName_702904 LastName_702904; FirstName_702904 LastName_702904; FirstName_702904 LastName_702904; FirstName_702904 LastName_702904; Mari-Liis Krupp; FirstName_702904 LastName_702904; FirstName_702904 LastName_702904; FirstName_702904 LastName_702904; FirstName_702904 LastName_702904; Gerli Viikmaa; FirstName_702904 LastName_702904Protobios OÜ
Patentne leiutisUS20000249508P16.11.2000Rahvusvaheline (IPC)Profiling tumor specific markers for the diagnosis and treatment of neoplastic diseaseFirstName_703723 LastName_703723CEMINES LLC
Patentne leiutisUS61/168,31910.04.2009Rahvusvaheline (IPC)Transgenic mouse and cell models and their uses for identification of drugs targeting brain-derived neurotrophic factorFirstName_706764 LastName_706764; FirstName_706764 LastName_706764; FirstName_706764 LastName_706764; FirstName_706764 LastName_706764; FirstName_706764 LastName_706764; FirstName_706764 LastName_706764; FirstName_706764 LastName_706764Tallinna Tehnikaülikool
Patentne leiutisUS61/306,62222.02.2010Rahvusvaheline (IPC)Treatment of proliferative disordersFirstName_703906 LastName_703906; FirstName_703906 LastName_703906Protobios OÜ
  • Leitud 1 kirjet
PealkiriValdkondKontaktisikAsutus
Aju molekulaarsed uuringud1. Bio- ja keskkonnateadused; 3. TerviseuuringudFirstName_1169737 LastName_1169737Protobios OÜ
  • Leitud 1 kirjet
NimetusAsutusVastutav isik
Immune Health DataProtobios OÜFirstName_707742 LastName_707742