FirstName_54649 LastName_54649

2.03.1951

Teenistuskäik

Töökohad ja ametid
2007–...    Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, Erakorraline professor (1,00)
01.01.2005–...    CePeP III AB, direktorite kolleegiumi juhataja, Stockholm, Rootsi
01.01.2005–...    Stockholmi Ülikool, Neurokeemia teaduskond, juhataja, Rootsi
01.01.2003–...    Stockholmi Ülikool, Neurokeemia teaduskond, Neurokeemia ja Molekulaarse neurobioloogia professor, Rootsi
01.01.2002–...    Ljubljana Ülikool, Arstiteaduskond, aukülalisprofessor, Sloveenia
01.01.2001–...    Scripps Uurimisinstituut, külalisprofessor, La Jolla, CA, USA,
01.01.1997–...    Tartu Ülikool, Arstiteaduskond, külalisprofessor, Tartu, Eesti
01.01.2003–31.12.2004    Orexo AB, direktorite kolleegiumi liige, Uppsala, Rootsi
01.01.2003–31.12.2004    Stockholmi Ülikool, Neurokeemia ja Neurotoksikoloogia teaduskond, juhataja asetäitja, Stockholm, Rootsi
01.01.2001–31.12.2003    CePeP AB, direktorite kolleegiumi juhataja, Stockholm, Rootsi
01.01.2001–31.12.2003    Stockholmi Ülikool, Neurokeemia ja Neurotoksikoloogia teaduskond, Neurokeemia ja Neurotoksikoloogia professor, Stockholm, Rootsi
01.01.2000–31.12.2001    The Harold L. Dorris Neuroloogia uurimiskeskus, Neurofarmakoloogia teaduskond, dotsent,The Scripps Research Institute, La Jolla, CA, USA
01.01.1997–31.12.1999    Projektijuht (biosensorid miinide otsimiseks), Bofors, Rootsi
01.01.1997–31.12.2002    Stockholmi Ülikool, Neurokeemia ja Neurotoksikoloogia teaduskond, õppeprorektor, Rootsi
01.01.1992–31.12.2001    Stockholmi Ülikool, Neurokeemia ja Neurotoksikoloogia, lektor ja dotsent, Stockholm, Rootsi
01.01.1987–31.12.1991    Stockholmi Ülikool, Biokeemiateaduskond, külalisteadur, Stockholm, Rootsi
1980–1989    Tartu Ülikool, Arstiteaduskond, Dotsent (1,00)
1974–1980    Tartu Ülikool, Füüsika-keemiateaduskond, Orgaanilise ja bioorgaanilise keemia instituut, Teadur (1,00)
 
 
Haridustee
1974–1980    Tartu Ülikool, Doktoriõpe, bioorgaanilises keemias, PhD
1969–1974    Tartu Ülikool, Keemiaosakond, bioorgaanilises keemias, BcS
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
1996−...    Neuroteaduste Ühing, Rahvusvaheline Neurokeemia Ühing, Euroopa Peptiidie Ühing, Rootsi Biokeemia Ühing, Eesti Biokeemia Ühing
1996−...    teaduslik retsensent NIH, wellcome trust, INSERM etc.
1995−...    Rahvusvaheline Neuropeptiidide Ühingu liige
2005−2005    Külaliseditor, Current Pharmaceutical Design
2003−2005    Ajakirja "Drug Design Reviews-Online” toimetuse liige
2000−2000    Eesti Biomeditsiini keskuse rahvusvahelise ekspertkomisjoni liige
 
 
Teenistuskäigu lisainfo
Külalisloengud : rohkem kui 50 ajavhemikul 1995-2008 ;
Teaduslike konverentside organiseerija: Neuropeptiid -galaniin, San Diego 2004, koos T Yaksh, T. Bartfai, and T. Hökfelt.
Rakku tungivad peptiidid, Stockholm, 2005, Wenner-Gren Conference
;
Põhijuhendaja 10 PhD tudengil, kellel on kavas kaitsta doktorikraad vahemikus 2008-2014. Umbes 20 järeldoktorantuuri granti aastast 1997 kuni tänaseni.;

Kvalifikatsioon

 
 
Teaduspreemiad ja tunnustused
2009, FirstName_54649 LastName_54649, Eesti riiklik teaduspreemia
2001, FirstName_54649 LastName_54649, White Star Order, 4th class, from Estonian Republic,
 
 
Teadustöö põhisuunad
VALDKOND: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; PÕHISUUND: Rakku tungivad peptiidid

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.2.
2013
3.1.
2013
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.2.
2012
1.2.
2012
1.2.
2012
3.1.
2012
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.2.
2011
1.2.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.2.
2010
3.4.
2010
5.1.
2010
5.1.
2010
5.1.
2010
5.1.
2010
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
3.1.
2009
3.1.
2009
3.1.
2009
3.4.
2009
5.1.
2009
5.2.
2009
5.2.
2009
6.3.
2009
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.2.
2007
3.1.
2007
3.1.
2007
5.1.
2007
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.2.
2006
1.2.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
5.1.
2006
5.1.
2006
6.7.
2006
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.2.
2005
1.2.
2005
1.2.
2005
3.1.
2005
5.1.
2005
5.2.
2005
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.2.
2004
3.2.
2004
5.1.
2004
5.2.
2004
6.6.
2004
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.2.
2001
1.3.
2001
3.4.
2001
3.4.
2001
5.1.
2001
1.1.
2000
1.1.
2000
1.1.
2000
3.1.
2000
3.2.
2000
3.2.
2000
1.1.
1999
1.1.
1999
1.1.
1999
1.1.
1999
1.2.
1999
1.2.
1999
3.1.
1999
3.1.
1999
6.2.
1999
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.2.
1998
1.2.
1998
1.2.
1998
1.2.
1998
1.2.
1998
1.2.
1998
5.2.
1998
6.2.
1998
6.2.
1998
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.2.
1997
1.2.
1997
1.1.
1996
1.1.
1996
1.1.
1996
1.1.
1996
1.2.
1996
1.2.
1996
2.2.
1996
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.2.
1995
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1991
1.1.
1991
1.1.
1991
1.1.
1991
1.1.
1991
3.1.
1991
3.1.
1991
3.1.
1991
1.1.
1990
1.1.
1990
5.1.
1990
1.1.
1989
1.1.
1989
1.2.
1987
1.2.
1987
1.3.
1987
1.1.
1986
1.1.
1986
1.1.
1986
1.1.
1984
1.1.
1984
1.2.
1984
1.2.
1982
1.1.
1981
1.1.
1980
1.1.
1979
1.1.
1978
1.1.
1978
1.1.
1978
1.1.
1978
1.1.
1978
1.1.
1976
1.3.
1974

FirstName_54649 LastName_54649

2.03.1951

Career

Institution and position
2007–...    University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Professor extraordinarius (1,00)
01.01.2005–...    Chairman of the board of Directors of the CePeP III AB, Stockholm, Sweden
01.01.2005–...    Chair, Dept. Neurochemistry, Stockholm University, Sweden
01.01.2003–...    Professor of neurochemistry and molecular neurobiology, Dept. Neurochemistry, Stockholm University, Sweden
01.01.2002–...    Honorary Visiting Professor, Medical Faculty, Ljubljana University, Slovenia
01.01.2001–...    Adjunct Visiting Professor, The Scripps Research Institute, La Jolla, CA, USA
01.01.1997–...    Visiting Professor, Faculty of Medicine, Tartu University, Tartu, Estonia
01.01.2003–31.12.2004    Member of the board of Directors of the Orexo AB, Uppsala, Sweden
01.01.2003–31.12.2004    Deputy Chairman, Dept. Neurochemistry and Neurotoxicology, Stockholm University, Sweden
01.01.2001–31.12.2003    Chairman of the board of Directors of the CePEP AB, Stcockholm, Sweden
01.01.2001–31.12.2003    Professor of neurochemistry and neurotoxicology, Dept. Neurochemistry and Neurotoxicology, Stockholm University, Sweden
01.01.2000–31.12.2001    Associate Professor, The Harold L. Dorris Neurological Research Center, Dept. of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
01.01.1997–31.12.1999    Project leader (chemistry of biosensors for mine detection) at Bofors Sweden, part time
01.01.1997–31.12.2002    Director of studies, Dept. Neurochemistry and Neurotoxicology, Stockholm University, Sweden
01.01.1992–31.12.2001    Lecturer and Associate Professor, Dept. Neurochemistry and Neurotoxicology, Stockholm University, Sweden
01.01.1987–31.12.1991    Visiting research fellow, Dept. Biochemistry, Stockholm University, Sweden
1980–1989    University of Tartu, Faculty of Medicine, Associate Professor (1,00)
1974–1980    University of Tartu, Faculty of Physics and Chemistry, Institute of Organic and Bioorganic Chemistry, Researcher (1,00)
 
 
Education
1974–1980    Tartu University,Bioorganic chemistry, PhD
1969–1974    Department of Chemistry, Tartu University, Bioorganic chemistry, BcS
 
 
R&D related managerial and administrative work
1996−...    Society of Neuroscience, International Society for Neurochemistry, European Peptide Society, Swedish Biochemical Society, Estonian Biochemical Society
1996−...    Scientific reviewer of: NIH, wellcome Trust, INSERM etc.
1995−...    Fellow member of International Neuropeptide Society
2005−2005    Guest Editor, Current Pharmaceutical Design
2003−2005    Editorial Advisory Board Member of the journal “Drug Design Reviews-Online”
2000−2000    Member of International review Board for the Estonian centre of Excellence in Biomedicine, Tartu
 
 
Additional career information
Invited lecturer : more than 50 in 1995-2008 ;
Organiser of scientific conferences: Neuropeptide galanin, San Diego 2004, together with T Yaksh, T. Bartfai, and T. Hökfelt
Cell-penetrating peptides, Stockholm 2005, Wenner-Gren Conference;
Main supervisor for 10 PhD students planned to defend the thesis in 2008-2014.
Post-doctoral fellows: ca 20 in 1997-...now;

Qualifications

 
 
Honours & awards
2009, FirstName_54649 LastName_54649, The National Science Award of the Rebublic of Estonia
2001, FirstName_54649 LastName_54649, White Star Order, 4th class, from Estonian Republic,
 
 
Field of research
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.1. Biochemistry; SPECIALITY: Cell penetrating peptides
 
 

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2013
1.2.
2013
3.1.
2013
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.2.
2012
1.2.
2012
1.2.
2012
3.1.
2012
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.2.
2011
1.2.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
3.1.
2011
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.2.
2010
3.4.
2010
5.1.
2010
5.1.
2010
5.1.
2010
5.1.
2010
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
3.1.
2009
3.1.
2009
3.1.
2009
3.4.
2009
5.1.
2009
5.2.
2009
5.2.
2009
6.3.
2009
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.2.
2007
3.1.
2007
3.1.
2007
5.1.
2007
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.2.
2006
1.2.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
3.1.
2006
5.1.
2006
5.1.
2006
6.7.
2006
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.1.
2005
1.2.
2005
1.2.
2005
1.2.
2005
3.1.
2005
5.1.
2005
5.2.
2005
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2004
1.2.
2004
3.2.
2004
5.1.
2004
5.2.
2004
6.6.
2004
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
3.1.
2002
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2001
1.2.
2001
1.3.
2001
3.4.
2001
3.4.
2001
5.1.
2001
1.1.
2000
1.1.
2000
1.1.
2000
3.1.
2000
3.2.
2000
3.2.
2000
1.1.
1999
1.1.
1999
1.1.
1999
1.1.
1999
1.2.
1999
1.2.
1999
3.1.
1999
3.1.
1999
6.2.
1999
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.1.
1998
1.2.
1998
1.2.
1998
1.2.
1998
1.2.
1998
1.2.
1998
1.2.
1998
5.2.
1998
6.2.
1998
6.2.
1998
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.1.
1997
1.2.
1997
1.2.
1997
1.1.
1996
1.1.
1996
1.1.
1996
1.1.
1996
1.2.
1996
1.2.
1996
2.2.
1996
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.1.
1995
1.2.
1995
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1994
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1993
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1991
1.1.
1991
1.1.
1991
1.1.
1991
1.1.
1991
3.1.
1991
3.1.
1991
3.1.
1991
1.1.
1990
1.1.
1990
5.1.
1990
1.1.
1989
1.1.
1989
1.2.
1987
1.2.
1987
1.3.
1987
1.1.
1986
1.1.
1986
1.1.
1986
1.1.
1984
1.1.
1984
1.2.
1984
1.2.
1982
1.1.
1981
1.1.
1980
1.1.
1979
1.1.
1978
1.1.
1978
1.1.
1978
1.1.
1978
1.1.
1978
1.1.
1976
1.3.
1974
  • Leitud 10 kirjet
ProgrammNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusRahastamine kokku
MUULLOTI09164CEPEP Eesti Oü kasvajavastaste toimeainete rakkuviimiseks disainitud selektiivsete transportpeptiidide katsetamine ja hindamine, in silico, in vitro ja in vivo27.11.200925.04.2010FirstName_719573 LastName_719573Tartu Ülikool89 476,31 EUR
MJDMJD64Design, Synthesis and Applications of New Chimeric CPPs for Intracellular Delivery of Nucleic Acids and Drugs01.03.201030.06.2013FirstName_729678 LastName_729678Tartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut92 376,49 EUR
SFSF0180027s08Koespetsiifilised transportvektorid01.01.200831.12.2013FirstName_731552 LastName_731552Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut600 272,61 EUR
TKTK143Molekulaarse Rakutehnoloogia Tippkeskus01.01.201601.03.2023FirstName_946522 LastName_946522Tartu Ülikool, Loodus- ja täppisteaduste valdkond, Tehnoloogiainstituut3 917 568,00 EUR
MUUVLOTI13123Seksuaalsel teel levivate haigustekitajate molekulaardiagnostilise detekteerimistehnoloogia arendamine01.05.201331.10.2014FirstName_717654 LastName_717654Tartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut709 284,00 EUR
IUTIUT20-26Trans-barrier targeting01.01.201431.12.2019FirstName_1024334 LastName_1024334Tartu Ülikool, Loodus- ja täppisteaduste valdkond, Tehnoloogiainstituut592 800,00 EUR
ETFETF9438Uued meetodid therapeutikumide raku spetsiifiliseks sisestamiseks01.01.201201.12.2015FirstName_1106232 LastName_1106232Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut46 440,00 EUR
APIUT20-26AP14Väikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema IUT20-26 raames01.01.201431.10.2015FirstName_730535 LastName_730535Tartu Ülikool, Loodus- ja tehnoloogiateaduskond64 000,00 EUR
APSF0180027s08APVäikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180027s08 raames01.01.201031.12.2011FirstName_730546 LastName_730546Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut58 798,72 EUR
APSF0180027s08AP11Väikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180027s08 raames01.01.201131.12.2012FirstName_730563 LastName_730563Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut60 376,76 EUR
  • Leitud 406 kirjet
PublikatsioonKlassifikaatorFail
Juks, C.; Lorents, A.; Arukuusk, P.; Langel, Ü.; Pooga, M. (2017). Cell penetrating peptides recruit type A scavenger receptors to the plasma membrane for cellular delivery of nucleic acids. The FASEB Journal, xxx−xxx, 10.1096/fj.201600811r [ilmumas].1.1.
Cerrato, Carmine Pasquale; Künnapuu, Kadri; Langel, Ülo (2017). Cell-penetrating peptides with intracellular organelle targeting. Expert Opinion on Drug Delivery, 14 (2), 245−255, 10.1080/17425247.2016.1213237.1.1.
Jekaterina Jevtuševskaja, Katrin Krõlov, Indrek Tulp & Ülo Langel (2017). The effect of main urine inhibitors on the activity of different DNA polymerases in loop-mediated isothermal amplification. Journal Expert Review of Molecular Diagnostics , 1−9, 14737159.2017.1283218.1.1.
Pärnaste, Ly; Arukuusk, Piret; Langel, Kent; Tenson, Tanel; Langel, Ülo (2017). The formation of nanoparticles between small interfering RNA and amphipathic cell-penetrating peptides. Molecular Therapy - Nucleic Acids, 7, 1−10, 10.1016/j.omtn.2017.02.003.1.1.
Margus, Helerin; Arukuusk, Piret; Langel, Ülo; Pooga, Margus (2016). Characteristics of Cell-Penetrating Peptide/Nucleic Acid Nanoparticles. Molecular pharmaceutics, 13 (1), 172−179, 10.1021/acs.molpharmaceut.5b00598.1.1.
Jevtuševskaja J, Uusna J, Andresen L, Krõlov K, Laanpere M, Grellier T, Tulp I, Langel Ü. (2016). Combination with antimicrobial peptide lyses improves loop-mediated isothermal amplification based method for Chlamydia trachomatis detection directly in urine sample. BMC Infectious Disease, 16 (329), 329, s12879-016-1674-0.1.1.
Pae, J.; Liivamägi, L.; Etverk, I.; Lubenets, D.; Arukuusk, P.; Langel, Ü.; Pooga, M. (2016). Glycosaminoglycans are required for translocation of amphipathic cell-penetrating peptides across membranes. Biochimica et Biophysica Acta-Biomembranes, 1858 (8), 1860−1867, 10.1016/j.bbamem.2016.04.010.1.1.
Freimann, Krista; Arukuusk, Piret; Kurrikoff, Kaido; Vasconcelos, Luís Daniel Ferreira; Veiman, Kadi-Liis; Uusna, Julia; Margus, Helerin; Garcia-Sosa, Alfonso T; Pooga, Margus; Langel, Ülo (2016). Optimization of in vivo DNA delivery with NickFect peptide vectors. Journal of controlled release : official journal of the Controlled Release Society, 241, 135−143, 10.1016/j.jconrel.2016.09.022.1.1.
Urgard, Egon; Lorents, Annely; Klaas, Mariliis; Padari, Kärt; Viil, Janeli; Runnel, Toomas; Langel, Kent; Kingo, Külli; Tkaczyk, Eric; Langel, Ülo; Maimets, Toivo; Jaks, Viljar; Pooga, Margus; Rebane, Ana (2016). Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis. Journal of Controlled Release, 235, 195−2014, 10.1016/j.jconrel.2016.06.006.1.1.
Kurrikof, Kaido; Gestin, Maxime; Langel, ܜlo (2016). Recent in vivo advances in cell-penetrating peptide-assisted drug delivery. Expert Opinion on Drug Delivery, 0 (0), 373−387, 10.1517/17425247.2016.1125879.1.1.
Srimanee, Artita; Regberg, Jakob; Hällbrink, Mattias; Vajragupta, Opa; Langel, Ülo (2016). Role of scavenger receptors in peptide-based delivery of plasmid DNA across a blood-brain barrier model. International journal of pharmaceutics, 500, 128−135, 10.1016/j.ijpharm.2016.01.014.1.1.
Urgard, E.; Lorents, A.; Klaas, M.; Padarik, K.; Viil, J.; Runnel, T.; Ü Langel; Jaks, V.; Pooga, M.; Rebane, A.; (2016). 314 PepFect6-miRNA-146a nanocomplexes inhibit inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis. <i>136.</i> European Society for Dermatological Research (ESDR), S214. (9, Supplement 2).3.1.
Kurrikoff, K.; Veiman, K.-L.; Langel, Ü. (2015). CPP-based delivery system for in vivo gene delivery (Methods in Molecular Biology). Methods in molecular biology, 1324, 339−347, 10.1007/978-1-4939-2806-4_22.1.1.
Freimann, Krista; Kurrikoff, Kaido; Langel, Ülo (2015). Galanin receptors as a potential target for neurological disease. Expert Opinion on Therapeutic Targets, 19 (12), 1−12.1.1.
Pärnaste, Ly; Arukuusk, Piret; Zagato, Elisa; Braeckmans, Kevin; Langel, Ülo (2015). Methods to follow intracellular trafficking of cell-penetrating peptides. Journal of Drug Targeting, 24 (6), 508−519, 10.3109/1061186X.2015.1095194.1.1.
Veiman, Kadi-Liis; Künnapuu, Kadri; Lehto, Tõnis; Kiisholts, Kristina; Pärn, Kalle; Langel, Ülo; Kurrikoff, Kaido (2015). PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo. Journal of Controlled Release, 209, 238−247, 10.1016/j.jconrel.2015.04.038.1.1.
Arukuusk, P.; Pärnaste, L.; Hällbrink, M.; Langel, Ü. (2015). Pepfects and nickfects for the intracellular delivery of nucleic acids (Methods in Molecular Biology). Methods in molecular biology, 1324, 303−315, 10.1007/978-1-4939-2806-4_19.1.1.
Pärn, K.; Eriste, E.; Langel, Ü. (2015). The antimicrobial and antiviral applications of cell- penetrating peptides (Methods in Molecular Biology). Methods in molecular biology, 1324, 223−245, 10.1007/978-1-4939-2806-4_15.1.1.
Juks, C.; Padari, K.; Margus, H.; Kriiska, A.; Etverk, I.; Arukuusk, P.; Koppel, K.; Ezzat, K.; Langel, Ü.; Pooga, M. (2015). The role of endocytosis in the uptake and intracellular trafficking of PepFect14-nucleic acid nanocomplexes via class A scavenger receptors. Biochimica et Biophysica Acta-Biomembranes, 1848 (12), 3205−3216, 10.1016/j.bbamem.2015.09.019.1.1.
Uusna, J.; Langel, K.; Langel, Ü. (2015). Toxicity, immunogenicity, uptake, and kinetics methods for CPPs (Methods in Molecular Biology). Methods in molecular biology, 1324, 133−148, 10.1007/978-1-4939-2806-4_9.1.1.
Cerrato, Carmine; Veiman, Kadi-Liis; Langel, Ülo (2015). Advances in peptide delivery. In: Advances in the Discovery and Development of Peptide Therapeutics (160−171). Future Science Group.1.2.
Pooga, Margus; Langel, Ülo (2015). Classes of cell-penetrating peptides. In: Ü. Langel (Ed.). Methods in Molecular Biology (3−28). Springer.3.1.
Pärn, K.; Eriste, E.; Langel, Ü. (2015). The Antimicrobial and Antiviral Applications of Cell-Penetrating Peptides. In: Langel Ülo (_EditorsAbbr). Cell-Penetrating Peptides (223−245). Springer New York. (1324).3.1.
Copolovici, D; Langel, K; Eriste, E; Langel, Ü (2014). Cell-Penetrating Peptides: Design, Synthesis, and Applications. ACS Nano, 8 (3), 1972−1994, 10.1021/nn4057269.1.1.
Vasconcelos, Luis; Madani, Fatemeh; Arukuusk, Piret; Pärnaste, Ly; Gräslund, Astrid, Langel, Ülo (2014). Effects of cargo molecules on membrane perturbation caused by transportan10 based cell-penetrating peptides. Biochimica et Biophysica Acta, 1838 (12), 3118−3129, 10.1016/j.bbamem.2014.08.011.1.1.
  • Leitud 53 kirjet
PealkiriJuhendatavKraadJuhendajaKaitsmise staatusKaitsmise aastaAsutus
Development of a prodrug strategy for vectors based on cell penetrating peptides - doktorikraadFirstName_695835 LastName_695835; FirstName_695835 LastName_695835JuhendamiselTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut
A novel GalR2-specific peptide agonist - magistrikraadFirstName_693660 LastName_693660; FirstName_693660 LastName_693660Kaitstud2009Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Keemia Instituut, Orgaanilise keemia õppetool
A novel strategy for peptide-mediated cellular delivery and induction of endosomal escape - doktorikraadFirstName_695796 LastName_695796Kaitstud2011Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Keemia Instituut
Aktiveeritavate rakku sisenevate peptiidide süntees ning rakendamine geeni transpordiks in vitro ning in vivo tingimustes - magistrikraadFirstName_695826 LastName_695826; FirstName_695826 LastName_695826Kaitstud2014Tartu Ülikool, Loodus- ja tehnoloogiateaduskond
Amüloid beta-peptiidide efektid aju signaalülekandes - magistrikraad (teaduskraad)FirstName_694868 LastName_694868; FirstName_694868 LastName_694868; FirstName_694868 LastName_694868Kaitstud2000Tartu Ülikool, Füüsika-keemiateaduskond
Application of antimicrobial peptides in human sexually transmitted bacterial pathogens detection - doktorikraadFirstName_695834 LastName_695834; FirstName_695834 LastName_695834JuhendamiselTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut
Applications of cell-penetrating peptides in regulation of gene expressionHenrik JohanssondoktorikraadFirstName_695804 LastName_695804Kaitstud2008Stockholmi Ülikool
Applications of NickFects vectors for breast cancer targeting - doktorikraadFirstName_695836 LastName_695836; FirstName_695836 LastName_695836JuhendamiselTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut
Assessing cytoplasmic delivery mechanisms of luciferin-conjugated cell-penetrating peptides using a novel bioluminescence based assay - magistrikraadFirstName_641410 LastName_641410; FirstName_641410 LastName_641410Kaitstud2011Tartu Ülikool, Loodus- ja tehnoloogiateaduskond
Cell-penetarting peptides. Mechanisms and applications - doktorikraadFirstName_695808 LastName_695808Kaitstud2000The Department of Neurochemistry and Neurotoxicology, Stockholm University
Cell-penetrating peptide mechanism studies:from peptides to cargo delivery - doktorikraadFirstName_695827 LastName_695827Kaitstud2014Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut
Cell-penetrating peptide, transportan, and its predecessors, galanin-based chimeric peptides - doktorikraadFirstName_687402 LastName_687402Kaitstud1998Tartu Ülikool
Cell-penetrating peptides and bioactive cargoes. Strategies and mechanisms - doktorikraadFirstName_662636 LastName_662636Kaitstud2004Stockholmi Ülikool
Cell-penetrating peptides for the nanoparticle-based vectorization of oligonucleotides - doktorikraadFirstName_695830 LastName_695830JuhendamiselTartu Ülikool, Loodus- ja tehnoloogiateaduskond
Cell-penetrating peptides in cargo delivery. In vitro stydies on uptake and in vivo studies on tumor targetingHelena MyrbergdoktorikraadFirstName_695803 LastName_695803Kaitstud2008Stockholmi Ülikool
Cell-penetrating peptides: Cellular uptake and biological activitiesAnna ElmquistdoktorikraadFirstName_669745 LastName_669745Kaitstud2003Stockholmi Ülikool
Cell-penetrating peptides: cytotoxicity, immunogenicity and application for tumor targeting - doktorikraadFirstName_695795 LastName_695795Kaitstud2012Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut
Cell-penetrating peptides: Uptake, stability and biological activityTina HolmdoktorikraadFirstName_695797 LastName_695797Kaitstud2011Stockholmi Ülikool
Cell-penetrating properties of peptides derived from proteins involved in Alzheimer's diseasePontus Lundbergmagistrikraad (teaduskraad)FirstName_694672 LastName_694672; FirstName_694672 LastName_694672Kaitstud2002Stockholmi Ülikool
Characterization of cell-penetrating peptides: assessment of cellular internalization kinetics, mechanisms and - doktorikraadFirstName_641406 LastName_641406Kaitstud2011Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut
Delivery of nucleic acids by cell-penetrating peptides: application in modulation of gene expression - doktorikraadFirstName_681446 LastName_681446Kaitstud2011Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut
Design and synthesis of PEG-CPP-oligonucleotide complexes - magistrikraadFirstName_695833 LastName_695833JuhendamiselTartu Ülikool, Loodus- ja tehnoloogiateaduskond
Design of GalR2 subtype specific ligands: their role in depression-like behavior and feeding regulation - doktorikraadFirstName_695794 LastName_695794; FirstName_695794 LastName_695794Kaitstud2013Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Keemia Instituut
Design, construction and production of cell penetrating recombinant proteins - doktorikraadFirstName_695829 LastName_695829; FirstName_695829 LastName_695829; FirstName_695829 LastName_695829JuhendamiselTartu Ülikool
Development of BBB passing galanin receptor ligandsKristin KarlssondoktorikraadFirstName_695832 LastName_695832JuhendamiselStockholmi Ülikool
  • Leitud 6 kirjet
TüüpPrioriteedi numberPrioriteedi kuupäevPrioriteedi klassifikaatorPealkiriAutoridFailAsutused
Patentne leiutis0002232-715.06.2000Rahvusvaheline (IPC) GLUTHIONE ANALOGUES AND THEIR USE AS ANTIOXIDANTSFirstName_703638 LastName_703638; FirstName_703638 LastName_703638; FirstName_703638 LastName_703638; FirstName_703638 LastName_703638Vulpes Ltd
Patentne leiutisEP1115527522.02.2011Rahvusvaheline (IPC)A system for cargo delivery into the cellsFirstName_704243 LastName_704243; FirstName_704243 LastName_704243; FirstName_704243 LastName_704243; FirstName_704243 LastName_704243Cepep Eesti OÜ
Patentne leiutisSE20020001863; US20020391788P18.06.2002Rahvusvaheline (IPC)Cell penetrating peptidesFirstName_703903 LastName_703903; Mattias Hällbrink; FirstName_703903 LastName_703903; FirstName_703903 LastName_703903; FirstName_703903 LastName_703903; Maria Lindgren; FirstName_703903 LastName_703903; Claes Göran Östensson; Metka Budihna; FirstName_703903 LastName_703903; Anna Elmquist; FirstName_703903 LastName_703903; FirstName_703903 LastName_703903; FirstName_703903 LastName_703903; FirstName_703903 LastName_703903; FirstName_703903 LastName_703903; FirstName_703903 LastName_703903; FirstName_703903 LastName_703903; FirstName_703903 LastName_703903CEPEP AB
Patentne leiutisEP1217116012.06.2012Rahvusvaheline (IPC)Chimeric constructs between glioma-homing peptide and cell-penetrating peptides, gHoPe2FirstName_707208 LastName_707208; FirstName_707208 LastName_707208; FirstName_707208 LastName_707208; FirstName_707208 LastName_707208; FirstName_707208 LastName_707208Cepep III AB;
Tartu Ülikool;
University of Wolverhampton
Patentne leiutisUS61/716,495 20.10.2012Rahvusvaheline (IPC)Method and its compositions for detection of nucleic acid target from biological samples and body fluidsFirstName_704506 LastName_704506; FirstName_704506 LastName_704506; FirstName_704506 LastName_704506; FirstName_704506 LastName_704506Selfdiagnostics OÜ
Patentne leiutisP20100001329.01.2010Rahvusvaheline (IPC)Method and rapid test device for detection of target moleculeFirstName_704342 LastName_704342; FirstName_704342 LastName_704342; FirstName_704342 LastName_704342; FirstName_704342 LastName_704342; FirstName_704342 LastName_704342Selfdiagnostics OÜ